Immunolocalization of Vimentin in Macrophage-derived Giant Cells. Method for Obtaining Larger Giant Cells.

Giant cell myocarditis: evidence for the macrophage origin of the giant cells.

In order to elucidate the origin of giant cells in giant cell myocarditis a case has been studied immunohistologically using monoclonal antibodies against a variety of antigens, including those associated with muscle and macrophages. The results strongly suggest that the giant cells are derived from macrophages rather than the muscle cells.

HIV-1-Infected Macrophage Giant Cells Cytoskeletal Protein Transformation in

Macrophage fusion: the making of osteoclasts and giant cells

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell– specific transmembrane protein ...

Circulating Endothelial Giant Cells

Giant cells fully permissive for human cytomegalovirus (HCMV) were found to circulate, at a variable proportion, in peripheral blood of 21 out of 25 immunocompromised patients with disseminated HCMV infection. Circulating endothelial giant cells (EGC) were identified by a specific monoclonal antibody of endothelial origin and shown to express immediateearly, early, and late viral proteins. Immu...

Giant cells in arthritic synovium.

OBJECTIVES Giant cells are commonly present in inflamed synovium, often in close association with the intimal layer. The nature of these multinucleate cells has been reassessed using new cytochemical and immunochemical techniques. METHODS Cryostat sections of non-inflamed, rheumatoid arthritic and osteoarthritic synovia were analysed for the presence of CD68 and non-specific esterase, markers...